Magnesium Supplementation for Treatment of Mental Disorders

Already high before the start of the pandemic, the experiences of stress, anxiety, and depression have been exacerbated in the last two years of living through the COVID-19 pandemic, and have taken a critical toll on people’s overall well-being. The rate of depression in the United States alone has more than tripled compared to rates pre-pandemic.

One of the factors that can impact our overall mental health is the quality of food and nutrients that we consume. At Jost Chemical we are committed to continuing to develop the highest purity mineral salts which give our customers total confidence when formulating nutritional products that support the mental and physical health of humans. 

We offer many salts of magnesium, an essential and vital nutrient that is often deficient in today’s diets. The current RDA for adults is between 320 and 420mg daily, and the average US intake is around 250mg daily.¹ Research shows that treatment with magnesium supplementation has been used to:

• induce rapid recovery from depression,²
• improve symptoms of premenstrual syndrome,³ and 
• reduce hyperactivity in children with ADHD.⁴

Additionally, studies show that patients with schizophrenia have lower erythrocyte magnesium levels than control groups.⁵ Magnesium also plays a major role in calming the nervous system due to its ability to block brain N-methyl D-aspartate receptors (NMDA), thereby inhibiting excitatory neurotransmission.⁶ Conversely, inadequate magnesium levels can contribute to insomnia, seizures, anxiety, pain, and other neuropsychiatric problems.⁷,⁸

Contact us for more information regarding our high purity Magnesium salts.

Learn more about Magnesium: Nutrition, Innovation & Formulatory Performance

1. Institute of Medicine (IOM). Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Washington, DC: National Academy Press, 1997.
2. Eby GA, Eby KL. (2006). Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006 67(2), 362-70
3. Pearlstein T, Steiner M. Non-Antidepressant treatment of premenstrual syndrome.  Clinical Psychiatry. 2000; 61(12): 22-7.
4. Starobat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactive disorder (ADHD). Magnes Res. 1997; 10: 149-156.
5. Nechifor M. Interactions between magnesium and psychotropic drugs. Magnes Res. 2008; 21(2): 97-100.
6. Ruppersberg J et al. The mechanism of magnesium block of NMDA receptors. Seminars in Neuroscience. 1994;6(2): 87-96.
7. Djokic, Gorica et al. The Effects of Magnesium – Melatonin – Vit B Complex Supplementation in Treatment of Insomnia. Open access Macedonian journal of medical sciences vol. 7. 2019. 18 3101-3105.
8. Schwalfenberg, Gerry K, and Stephen J Genuis. The Importance of Magnesium in Clinical Healthcare. Scientifica vol. 2017 (2017): 4179326.