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Int J Biol Macromol. 2012 Jun
Optimized extraction of calcium malate from eggshell treated by PEF and an absorption assessment in vitro
Under optimized pulsed electric field (PEF) treatment for production of eggshell calcium malate (ESCM) by one-factor-at-a-time test and ternary quadratic regression orthogonal combination design (TQROCD), an absorption assessment of ESCM treated by the best conditions of PEF were performed in male mice with apparent calcium absorption rate (ACAR), serum alkalinity phosphatase (ALP), tartrate-resistant acid phosphatase…
J Anim Sci. 2016 Oct
Effect of disodium/calcium malate or supplementation on growth performance, carcass quality, ruminal fermentation products, and blood metabolites of heifers
The aim of this study was to assess the effects of malate salts and culture on growth performance, carcass quality, ruminal fermentation products, and blood metabolites in heifers raised under southern Europe practical farm conditions. A total of 108 Charolaise cross heifers (214 ± 27.3 kg BW and 6.4 ± 1.1 mo of age) were…
Bioresour Technol. 2013 Sep
High-level production of calcium malate from glucose by Penicillium sclerotiorum K302High-level production of calcium malate from glucose by Penicillium sclerotiorum K302
In this study, after screening of 9 fungal strains for their ability to produce calcium malate, it was found that Penicillium sclerotiorum K302 among them could produce high-level of calcium malate. Under the optimal conditions, the titer of calcium malate in the supernatant was 88.6 g/l at flask level. During 10-l fermentation, the titer of…
J Orthop Case Rep. 2018 Jul
A Randomized Open-Label Clinical Study Comparing the Efficacy, Safety, and Bioavailability of Calcium Lysinate with Calcium Carbonate and Calcium Citrate Malate in Osteopenia Patients
Introduction: Many factors influence bone health, but osteoporosis is viewed as a calcium deficiency disorder in which bone is resorbed to maintain the serum calcium levels. Dietary calcium supplements have been recommended for the prevention of osteoporosis in the elderly. Many forms of dietary calcium supplements are widely available in market, but products containing calcium citrate…
Altern Med Rev. 1999 Sep
Comparative absorption of calcium sources and calcium citrate malate for the prevention of osteoporosis
Anthropologically speaking, humans were high consumers of calcium until the onset of the Agricultural Age, 10,000 years ago. Current calcium intake is one-quarter to one-third that of our evolutionary diet and, if we are genetically identical to the Late Paleolithic Homo sapiens, we may be consuming a calcium-deficient diet our bodies cannot adjust to by…
Adv Food Nutr Res. 2008 Jan
The health benefits of calcium citrate malate: a review of the supporting science
There has been considerable investigation into the health benefits of calcium citrate malate (CCM) since it was first patented in the late 1980s. This chapter is a comprehensive summary of the supporting science and available evidence on the bioavailability and health benefits of consuming CCM. It highlights the important roles that CCM can play during…
J Nutr. 1994 Aug
Supplementation trials with calcium citrate malate: evidence in favor of increasing the calcium RDA during childhood and adolescence
The vast majority of peak adult bone mass is accumulated by the time longitudinal growth is complete. As peak bone mass is an important determinant of future fracture risk, the goal of the current calcium recommended dietary allowance during youth is to provide a calcium intake that allows individuals to reach their full genetic potential…
Poult Sci. 2002 Aug
An investigation of calcium citrate-malate as a calcium source for young broiler chicks
Two experiments were conducted to compare a sample of calcium citrate-malate (CC-M) with a sample of commercial-grade limestone in starting broiler chick diets. In the first experiment, with 0.7 or 0.9% calcium from limestone or CC-M, no differences in bone development (dry fat-free tibia, tibia weight, tibia ash, or tibia calcium) were observed due to…
Int J Biol Macromol. 2013 Jul
Assessment the levels of tartrate-resistant acid phosphatase (TRAP) on mice fed with eggshell calcium citrate malate
Optimized conditions were obtained by one-factor-at-a-time test (OFAT) and ternary quadratic regression orthogonal composite design (TQROCD) respectively. By pulse electric fields (PEF) technology, the process of eggshell calcium citrate malate (ESCCM), eggshell calcium citrate (ESCC) and eggshells calcium malate (ESCM) were comprehensive compared. The levels of tartrate-resistant acid phosphatase (TRAP) and the bioavailability on mice…
Food Chem. 2018 Apr