Copper 29 Cu 63.546

Cupric Sulfate Pentahydrate USP/EP Crystals

Jost Code: 2296

Synonyms: Blue Vitriol, Copper(II) sulfate pentahydrate, Sulfuric acid, copper(II) salt (1:1) pentahydrate, Copper II sulphate 5-hydrate

Cupric Sulfate Pentahydrate USP/EP Crystals can be used as a dietary ingredient and as a nutrient. Copper aids in the absorption of iron, in the formation of red blood cells and the proper bone formation and maintenance. Product specifications, SDSs and certifications are available under Additional Information.

Chemical Formula
CuSO4 · 5 H2O
CAS Number
7758-99-8
Molecular Weight
249.69
Use
Nutrient; Dietary Ingredient
Description
Blue crystals
Mineral Content (For formulation guidance/Not a specification)
Cu (typical): 25.0% - 25.6%
Containers
55 lb/25 kg carton
Storage
Store in a clean, dry warehouse in the original unopened containers. The product may agglomerate in storage. It may be gently deagglomerated and screened prior to use.
Revision Date
8/18/2022
Identification
Copper
Pass
Sulfate
Pass
Test A
Pass
Test C
Pass
Residual Solvents
Conforms to USP
LOD (USP)
33.0 - 36.5%
LOD (EP)
35.0 - 36.5%
Assay (USP)
98.5 - 100.5%
Assay (EP)
99.0 - 101.0%
Solution Appearance
Pass
Chloride
100 ppm maximum
Potassium
100 ppm maximum
Calcium
50 ppm maximum
Iron
30 ppm maximum
Sodium
200 ppm maximum
Nickel
20 ppm maximum
Lead
2 ppm maximum
Cobalt
1 ppm maximum
Microbial Test Results
Aerobic Plate Count
10³ cfu/g maximum
Yeast and Mold Count
10² cfu/g maximum
Total Coliforms
Negative
Technical Information
Related Articles
  • Frontiers in Bioscience. 2004 Sep Copper storage diseases: Menkes, Wilsons, and cancer

    The trace element copper is vital to the healthy functioning of organisms. Copper is used in a multitude of cellular activities including respiration, angiogenesis, and immune responses. Like other metals, copper homeostasis is a tightly regulated process. Copper is transported from dietary intake through the serum and into cells via a variety of transporters. There… Read Abstract

  • Survey of Ophthalmology. 2013 Nov Iron, zinc, and copper in retinal physiology and disease.

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  • Nature. 2014 May Copper is required for oncogenic BRAF signalling and tumorigenesis.

    The BRAF kinase is mutated, typically Val 600→Glu (V600E), to induce an active oncogenic state in a large fraction of melanomas, thyroid cancers, hairy cell leukaemias and, to a smaller extent, a wide spectrum of other cancers. BRAF(V600E) phosphorylates and activates the MEK1 and MEK2 kinases, which in turn phosphorylate and activate the ERK1 and… Read Abstract

  • Oncotarget. 2016 Jun Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution.

    Copper-ionophores that elevate intracellular bioavailable copper display significant therapeutic utility against prostate cancer cells in vitro and in TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) mice. However, the pharmacological basis for their anticancer activity remains unclear, despite impending clinical trails. Herein we show that intracellular copper levels in prostate cancer, evaluated in vitro and across disease… Read Abstract