Sodium Caprate Purified Powder

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• Drug Discovery Today. 2021 Apr New perspectives in oral peptide delivery

  Owing to their structural diversity, peptides are a unique source of innovative active ingredients. However, their development has been challenging because of their disadvantageous pharmacokinetic (PK) properties. Over the past decade, many attempts have been made to improve the oral bioavailability of peptide drugs. In this review, we highlight the most recent and promising techniques… Read Abstract

• Journal of Controlled Release. 1996 Aug Enhancement of the intestinal absorption of peptides and nonpeptides

  It is not uncommon for peptides and structurally-similar non-peptides to have poor intestinal permeability and low oral bioavailability. One possible way to solve a permeability problem is to formulate the compound with membrane permeation-enhancing excipients. Important criteria for success of this approach are: (1) achieving reproducible intestinal permeation, (2) doing so without causing toxicity, and… Read Abstract

• On Drug Delivery. 2015 Jan Oral peptide delivery: Technology landscape & current status

  In this review piece, Leila N Hassani, PhD, Scientist in the Novel Drug Delivery Technologies Group; Andy Lewis , PhD, Director of Novel Drug Delivery Technologies; and Joël Richard, PhD, Senior Vice-President, Peptides, all of Ipsen, provide an overview of the advantages provided, and challenges faced, by oral peptide delivery, and discuss the strengths and… Read Abstract

• Pharmaceutics. 2019 Feb Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)

  Salcaprozate sodium (SNAC) and sodium caprate (C10) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules. Their effects on intestinal epithelia were studied for over 30 years, yet there is still debate over their mechanisms of action. C10 acts via openings of epithelial… Read Abstract

• Biomaterials. 2013 Jan Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells

  Sodium caprate is a promising candidate for inducing drug absorption enhancement. The mechanism of that uptake-enhancing effect is not fully understood so far. We investigated how caprate acts in an established human intestinal cell line, HT-29/B6, on the transient opening of transcellular (across the cell membranes) and paracellular (across the tight junction) pathways. Sodium caprate… Read Abstract

• Therapeutic Delivery. 2011 Dec Oral peptide delivery: prioritizing the leading technologies

  In the late 1980s and early 1990s, oral delivery technologies for macromolecules, peptides and proteins mushroomed at tremendous rates due to a number of very promising preclinical studies. Interest from pharmaceutical companies in these technologies subsequently fell away from in the late 1990s owing to a series of clinical disappointments as many supposed ‘platform technologies’… Read Abstract

• Tissue Barriers. 2017 Jul Intestinal surfactant permeation enhancers and their interaction with enterocyte cell membranes in a mucosal explant system

  Intestinal permeation enhancers (PEs) are agents aimed to improve oral delivery of therapeutic drugs with poor bioavailability. The main permeability barrier for oral delivery is the intestinal epithelium, and PEs act to increase the paracellular and/or transcellular passage of drugs. Transcellular passage can be achieved by cell membrane permeabilization and/or by endocytic uptake and subsequent… Read Abstract

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