Sodium Caprylate NF/EP Powder

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• Drug Discovery Today. 2021 Apr New perspectives in oral peptide delivery

  Owing to their structural diversity, peptides are a unique source of innovative active ingredients. However, their development has been challenging because of their disadvantageous pharmacokinetic (PK) properties. Over the past decade, many attempts have been made to improve the oral bioavailability of peptide drugs. In this review, we highlight the most recent and promising techniques… Read Abstract

• Biologicals. 2010 Mar Validation of a simple, rapid and cost effective method for the estimation of caprylic acid and sodium caprylate from biological products using NEFA-C kit

  The method for the determination of caprylic acid and sodium caprylate from biological products was systematically validated using NEFA-C kit. The results obtained demonstrated that the kit method was simple, rapid, reliable, sensitive, reproducible and cost effective in comparison to the current methods i.e. colorimetric, High Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC) methods.… Read Abstract

• AAPS PharmSciTech. 2014 Apr The role of caprylate ligand ion on the stabilization of human serum albumin

  Sodium caprylate was added to a pharmaceutical-grade human serum albumin (HSA) to stabilize the product. In this study we have aimed to establish how caprylate ligand protects HSA from thermal degradation. The fatty acid stabilizer was first removed from commercial HSA by charcoal treatment. Cleaned HSA was made to 10% w/v in pH 7.4 buffered… Read Abstract

• Am J Vet Res. 2011 Mar In vitro antimicrobial properties of caprylic acid, monocaprylin, and sodium caprylate against Dermatophilus congolensis

  Objective: To determine antimicrobial effects of caprylic acid and its derivatives, monocaprylin and sodium caprylate, on Dermatophilus congolensis and to determine effects of caprylic acid on the ultrastructure of D congolensis by use of transmission electron microscopy (TEM). Sample: 3 strains of D congolensis (33411, 33413, and 14639). Procedures: Strains of D congolensis were incubated separately under anaerobic… Read Abstract

• J Food Prot. 2006 Sep Inactivation of escherichia coli O157:H7 in cattle drinking water by sodium caprylate

  Escherichia coli O157:H7 is an important foodborne pathogen. Cattle serve as one of the major reservoirs of E. coli O157:H7, excreting the pathogen in feces. Environmental persistence of E. coli O157:H7 is critical in its epidemiology on farms, and the pathogen has been isolated from cattle water troughs. Thus, there is a need for an… Read Abstract

• Protein Expr Purif. 2019 Dec Sodium caprylate induced precipitation post Protein A chromatography as an effective means for host cell protein clearance

  In downstream processing of monoclonal antibody (mAb), post Protein A neutralization and subsequent intermediate depth filtration are critical steps for host cell protein (HCP) clearance. Previous studies have shown that adding caprylic acid (CA) during neutralization can further improve HCP removal by promoting their precipitation. In this study, we replaced CA with its sodium salt… Read Abstract

• J Chromatogr A. 2013 Apr Caprylate as the albumin-selective modifier to improve IgG purification with hydrophobic charge-induction chromatography

  Hydrophobic charge-induction chromatography (HCIC) is a novel downstream bioprocessing technology for antibody purification and it has several advantages over traditional purification processes. However, its separation selectivity still needs to be improved. In this work, sodium caprylate (NaCA) was used as the selective modifier to improve IgG purification from serum albumin containing feedstock with a typical… Read Abstract

• J Chromatogr A.. 2013 Apr Caprylate as the albumin-selective modifier to improve IgG purification with hydrophobic charge-induction chromatography.

  Abstract Hydrophobic charge-induction chromatography (HCIC) is a novel downstream bioprocessing technology for antibody purification and it has several advantages over traditional purification processes. However, its separation selectivity still needs to be improved. In this work, sodium caprylate (NaCA) was used as the selective modifier to improve IgG purification from serum albumin containing feedstock with a… Read Abstract

• J Pharm Sci.. 1988 May Fluorescence study of the membrane-perturbing action of sodium caprylate as related to promotion of drug absorption.

  The medium-chain fatty acid sodium caprylate released 6-carboxyfluorescein (CF), a model compound of water-soluble drugs, from the rat small intestinal brush border membrane (BBM) vesicles and liposomes containing CF. Caprylate caused a decrease in the fluorescence polarization of dansyl chloride, fluorescein isothiocyanate, and eosin maleimide covalently labeled to BBM. This indicates a perturbation of the BBM. However,… Read Abstract

• Biol Trace Elem Res.. 2016 Jun Dosage Effect of Zinc Glycine Chelate on Zinc Metabolism and Gene Expression of Zinc Transporter in Intestinal Segments on Rat

  Abstract Zinc plays an essential role in various fundamental biological processes. The focus of this research was to investigate the dosage effect of zinc glycine chelate (Zn-Gly) on zinc metabolism and the gene expression of zinc transporters in intestinal segments. A total of 30 4-week-old SD rats were randomized into five treatment groups. The basal… Read Abstract

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